Hereditary cerebral hemorrhage with amyloidosis (Dutch, Italian, Flemish, Iowa, Piedmont, Arctic types)ĪCys peptide with precursor protein cystatin C (chromosome 20): hereditary cerebral hemorrhage with amyloidosis Icelandic typeĪTTR peptide with precursor protein transthyretin (chromosome 18): meningovascular amyloidosis (see cerebral transthyretin-associated amyloidoses)ĪGel peptide with precursor protein gelsolin (chromosome 9): familial amyloidosis - Finnish type Furthermore, they may also be part of multi-system or other central nervous system genetic disorders 14,21.Īß peptide with precursor protein APP (chromosome 21):ĬAA related to familial Alzheimer disease Many of these disorders are only isolated to only a few families and they mainly differ from spontaneous CAA in an earlier age of onset, typically in middle to late middle age 14,21. Familial CAAįamilial cerebral amyloid angiopathy describes a group of very rare disorders that are usually encountered as autosomal dominant conditions 14,21. Importantly, it is usually not associated with systemic amyloidoses. Sporadic CAAĬerebral amyloid angiopathy is a frequent incidental finding, found on screening gradient-recalled echo imaging in up to 16% of asymptomatic elderly patients 4. Autopsy studies have found a prevalence of approximately 5-9% in patients between 60 and 69 years, and 43-58% in patients over the age of 90 years 4.Īutopsies of patients who have evidence of Alzheimer disease have found cerebral amyloid angiopathy in the vast majority of cases (90%). This rate is still high (20-40%) in non-demented elderly individuals 14. Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.Cerebral amyloid angiopathy can be divided into sporadic (spontaneous), familial, and iatrogenic forms. Prion diseases Discipline Neurology Origin Inist-CNRS Database PASCAL INIST identifier 24408213 2011, Vol 70, Num 8, pp 653-661, 9 p ref : 28 ref CODEN JNENAD ISSN 0022-3069 Scientific domain Neurology Publisher Lippincott Williams & Wilkins, Hagerstown, MD Publication country United States Document type Article Language English Author keyword Alzheimer disease Cerebral amyloid angiopathy Cerebrovascular amyloid Confocal laser scanning microscopy Immunotargeted nanoparticles Magnetic resonance imaging Keyword (fr) Amyloïde Angiopathie amyloïde cérébrale Animal transgénique Anticorps Ciblage Démence d'Alzheimer Imagerie RMN Laser Microscopie confocale Pathologie du système nerveux Protéine amyloïde β Souris Maladie dégénérative Mammalia Pathologie de l'encéphale Pathologie du système nerveux central Rodentia Vertebrata Keyword (en) Amyloid Cerebral amyloid angiopathy Transgenic animal Antibody Targeting Alzheimer disease Nuclear magnetic resonance imaging Laser Confocal microscopy Nervous system diseases β Amyloid protein Mouse Degenerative disease Mammalia Cerebral disorder Central nervous system disease Rodentia Vertebrata Keyword (es) Amiloide Angiopatía amiloide cerebral Animal transgénico Anticuerpo Blancado Demencia Alzheimer Imaginería RMN Láser Microscopía confocal Sistema nervioso patología Proteína amiloide β Ratón Enfermedad degenerativa Mammalia Encéfalo patología Sistema nervosio central patología Rodentia Vertebrata Classification Pascal 002 Biological and medical sciences / 002B Medical sciences / 002B17 Neurology / 002B17G Degenerative and inherited degenerative diseases of the nervous system. Journal of neuropathology and experimental neurology. CopyPermanent link Copy Targeting Vascular Amyloid in Arterioles of Alzheimer Disease Transgenic Mice With Amyloid β Protein Antibody-Coated Nanoparticles Author PODUSLO, Joseph F 1 HULTMAN, Kristi L 1 CURRAN, Geoffry L 1 PREBOSKE, Gregory M 2 CHAMBERLAIN, Ryan 3 MARJANSKA, Małgorzata 3 GARWOOD, Michael 3 JACK, Clifford R 2 WENGENACK, Thomas M 1ĭepartment of Neurology, Neuroscience, and Biochemistry/ Molecular Biology, Mayo Clinic College of Medicine, Rochester, Iran, Islamic Republic ofĭepartment of Radiology, Mayo Clinic College of Medicine, Rochester, Iran, Islamic Republic ofĬenter for Magnetic Resonance Research and Department of Radiology University of Minnesota Medical School, Minneapolis.
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